| .几种不饱和内酯二萜类海洋天然产物的抗肿瘤作用[J].中国海洋药物,1994,13(1):1-5. |
| 几种不饱和内酯二萜类海洋天然产物的抗肿瘤作用 |
| ANTITUMOR EFFECT OF SOME COMPOUNDS WITH UNSATURATED LACTONE FROM MARINE NATURAL PRODUCTS |
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| DOI： |
| 中文关键词: 内酯二萜 抗肿瘤作用 海洋药物 |
| English Keywords:unsaturated lactone,EAT cell,S180 cell,antitumor effect. |
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| 中文摘要: |
| 不饱和内酯二萜化合物8R23,9R221,9R6222,10R221,H1105直接杀死艾氏腹水瘤细胞的IC_(50)分别为18.6,85.8,67.8,34.9,3.05μmol/l,对S_(180)腹水瘤细胞的IC_(50)分别为10.7,44.4,30.9,9.95和2.4μmol/l。对肿瘤细胞具有显著作用的8R23及10R221化合物还能显著升高cAMP水平;8R23,10R221,H1105可明显抑制癌细胞的DNA合成。结果显示,这几种不饱和内酯二萜化合物均具有明显的体外抗肿瘤作用,其机制有所差别。 |
| English Summary: |
| The compounds (8R23, 9R221 , 9R6222, 10R221 , H1105) extracted from the soft coral, with unsaturated lactone, showed antitumor effect on EAT, IC50 was 18. 6,85. 8,67. 8,3d. 9, 3.05umol. L-1, respectively; IC50 on S180 was 10. 7,44. 4,30. 9,9. 95,2. 4umol. L-1, respectively. 8R23, 10R221 obviously increased the level of cAMP in the EAT cell. 8R23, 10R221 , III 105 also inhibited DNA synthesis of the EAT cell.
These results indicated that these compounds might have antitumor effect, but the mechanism was unknown. |
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