| 宁哲,胡波,武改芳,等.微生物混合培养次级代谢产物及其生物活性研究进展[J].中国海洋药物,2024,43(5):76-86. |
| 微生物混合培养次级代谢产物及其生物活性研究进展 |
| Progress in research of secondary metabolites and their biological activities in microbial co-culturing |
| 投稿时间：2023-06-05 修订日期：2023-08-30 |
| DOI：10.13400/j.cnki.cjmd.2024.05.005 |
| 中文关键词: 混合培养 微生物 次级代谢产物 |
| English Keywords:co-cultivation microorganism secondary metabolites |
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| 中文摘要: |
| 微生物的活性次级代谢产物是药物先导化合物的重要来源,然而研究发现大部分微生物在单一的培养条件下,合成基因簇是处于沉默状态。为了充分利用微生物资源,混合培养是微生物激活沉默基因优势的方法之一,它能简单、快速激活微生物沉默的微生物合成基因簇,产生结构多样、高活性的次级代谢产物。近几年的微生物天然产物研究成果表明,微生物混合培养是产生多活性,增加天然产物多样性的有效方法。本文综述了2016-2022年间的微生物混合培养次级代谢产物及其生物活性的最新研究成果。 |
| English Summary: |
| In natural environments, microorganisms need to compete for resources in order to survive, inducing the biosynthesis of secondary metabolites and producing active secondary metabolites that are important sources of lead compounds for drugs. Under regular culture conditions, most microorganisms keep the biosynthetic gene clusters of secondary metabolites in a silent state. To fully utilize microbial resources, one of the methods to activate the silent biosynthetic gene clusters of microorganisms is to simulate their competitive environment through mixed culture. The advantage of mixed culture is the activation of the silent biosynthetic gene clusters of micro-organisms and the rapid production of structurally diverse and highly active secondary metabolites. The research results of microbial natural products in recent years show that co-cultivation is an effective way to produce excellent activity and secondary metabolite diversity. This article summarizes the latest research results of secondary metabolites and their biological activities in microbial co-culturing from 2016 to 2022. |
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