| 庞若尘,刘涛,张鑫宇,等.Dragocin家族海洋天然产物四氢吡咯母核的合成[J].中国海洋药物,2024,43(6):57-61. |
| Dragocin家族海洋天然产物四氢吡咯母核的合成 |
| Synthesis of tetrahydropyrrole skeleton of dragocin family marine natural products |
| 投稿时间：2023-04-12 修订日期：2023-05-08 |
| DOI：10.13400/j.cnki.cjmd.2024.06.003 |
| 中文关键词: 海洋天然产物 dragocin 四氢吡咯 |
| English Keywords:marine natural product dragocin tetrahydropyrrole |
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| 中文摘要: |
| 目的 采用化学合成的方法对dragocin家族海洋天然产物进行合成研究,完成了dragocin家族海洋天然产物四氢吡咯母核的合成。方法 以对二氧环己酮和氨基乙醛的衍生物为起始原料,经有机小分子催化的aldol反应、串联的氢化/还原胺化反应、丙酮叉迁移、氧化、格氏反应等步骤合成目标化合物。结果 以对二氧环己酮和氨基乙醛的衍生物为起始原料，经6步反应，以22%的总产率完成了dragocin家族海洋天然产物四氢吡咯母核的合成,为天然产物的合成提供了基础。 |
| English Summary: |
| Objective The synthetic study on dragocin family marine natural products was conducted. The construction of core tetrahydropyrrole skeleton was accomplished. Methods The target compound was synthesized from dioxanone and aminoacetaldehyde derivatives through organocatalytic aldol, tandem hydrogenation/ reductive amination, migration, oxidation, and Grignard reaction. Results The synthesis of core tetrahydropyrrole skeleton in dragocin family marine natural products was completed in 6 steps with 22% yield, providing a foundation for total synthesis of natural products. |
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