| .转hCu,Zn-SOD突变基因聚球藻抗氧化作用的研究[J].中国海洋药物,2007,26(6):10-12. |
| 转hCu,Zn-SOD突变基因聚球藻抗氧化作用的研究 |
| Effect of Synechococcus sp. PCC7942 with trans-mutated hCu, Zn-SOD-gene on antioxidation activities in mice |
| 投稿时间：2007-04-02 |
| DOI： |
| 中文关键词: 转hCu,Zn-SOD突变基因聚球藻 抗氧化 谷胱甘肽过氧化物酶 过氧化氢酶 超氧化物歧化酶 丙二醛 |
| English Keywords:Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene,antioxidation GSH-Px,CAT,SOD,MDA |
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| 中文摘要: |
| 目的研究转人铜锌超氧化物歧化酶(hCu,Zn-SOD)突变基因聚球藻口服后的生物活性。方法给小鼠灌服转hCu,Zn-SOD突变基因聚球藻20d,然后测定小鼠谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)和超氧化物歧化酶(SOD)活力以及丙二醛(MDA)含量。结果转hCu,Zn-SOD突变基因聚球藻可明显提高小鼠血清GSH-Px活力和全血血红蛋白CAT活性,显著提高小鼠血清和肝脏中Cu,Zn-SOD和总SOD(T-SOD)的活力,显著降低小鼠血清和肝脏的MDA含量。结论转hCu,Zn-SOD突变基因聚球藻有较强的抗氧化作用。 |
| English Summary: |
| Objective To study the biological activities of Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene.Methods Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD were administered orally for 20d to mice,then the activities of glutathione peroxidase(GSH-Px),catalase(CAT),superoxide dismutase(SOD) and the content of malondialdehyde(MDA) were determined.Results The activities of GSHPx in serum and the activities of CAT in blood increased obviously;the activity of SOD in serum and liver increased markedly;the content of MDA in serum and liver decreased obviously.Conclusion Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene had obvious antioxidant effect in vivo. |
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