| 张琦琦,刘迪,韩璐.基于疏水改性策略制备琼脂糖基超韧薄膜及其理化性能研究[J].中国海洋药物,2026,(5):-. |
| 基于疏水改性策略制备琼脂糖基超韧薄膜及其理化性能研究 |
| Agarose-based ultrathin tough film via hydrophobic modification: Synthesis, characterization, and functional performance |
| 投稿时间：2025-05-01 修订日期：2025-06-16 |
| DOI： |
| 中文关键词: 疏水改性 透明 超韧 琼脂糖基薄膜 |
| English Keywords:Hydrophobic modification transparency ultra-tough Agarose-based film |
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| 中文摘要: |
| 目的 利用疏水改性策略,使用丁酸酐对亲水多糖琼脂糖(Agarose)进行酯化改性,成功制备得到具有疏水性质的琼脂糖(BAA),进一步通过溶液浇铸-烘干法,制备得到一种透明且超韧的BAA薄膜；考察BAA薄膜的溶胀性能、透光率、力学性能和细胞相容性。方法 首先,通过酯化反应合成BAA,并利用核磁共振氢谱仪和傅里叶变换红外光谱仪对其化学结构进行表征。随后,利用溶液浇铸-烘干法进一步制备得到一种透明且超韧的BAA膜。对BAA膜进行了形貌观察,并通过溶胀率测试、透光率测定和力学性能测试对其理化性质进行系统评价。此外,采用CCK-8法评估BAA膜的细胞相容性,以验证其生物安全性。结果 基于疏水改性策略成功制备了BAA,并通过溶液浇铸-烘干法制备得到了透明且超韧的BAA薄膜,该薄膜表现出低溶胀率(39.27% ± 12.73%)、高透光率(82.09% ± 3.76%)、同时具备优异的机械性能,拉伸强度达34.38 MPa ± 0.24 MPa,展现出良好的韧性和可拉伸性。此外,CCK-8实验结果显示,BAA膜具有良好的细胞相容性。结论 本研究提出了一种简便有效的琼脂糖疏水改性方法,成功制备出兼具光学透明性、高机械强度及良好生物相容性的BAA薄膜。该材料在组织工程、创面敷料及柔性生物电子器件等领域展现出广阔的应用潜力。 |
| English Summary: |
| Objective The aim of this study was to employ a hydrophobic modification strategy by esterifying hydrophilic marine-derived agarose using butyric anhydride to successfully prepare agarose (BAA) with hydrophobic motifs; and then fabricating a transparent and ultra-tough BAA film by a solution casting-drying method. Subsequently, the swelling properties, transparency, mechanical properties, and cytocompatibility of the BAA film were investigated. Methods Firstly, BAA was synthesized by esterification reaction and its chemical structure was characterized by NMR hydrogen spectroscopy and Fourier transform infrared spectroscopy. Subsequently, a transparent and super-tough BAA film was further prepared using the solution casting-drying method. The BAA film was observed morphologically, and its physicochemical properties were systematically evaluated by dissolution rate test, light transmittance evaluation and mechanical property test. In addition, the cytocompatibility of BAA film was evaluated using the CCK-8 assay to verify its biosafety. Results BAA was successfully synthesized based on the hydrophobic modification strategy, and transparent and ultra-tough BAA film was fabricated by solution casting-drying method, which exhibited low swelling ratio (39.27% ± 12.73%), high transparency (82.09% ± 3.76%), and excellent tensile properties, with a tensile strength of 34.38 MPa ± 0.24 MPa, and showed good toughness and stretchability. In addition, the results of CCK-8 experiments showed that BAA film have good cytocompatibility. Conclusion In this study, a simple and effective hydrophobic modification method of agarose was proposed, and BAA film with optical transparency, high mechanical strength and good biocompatibility were successfully prepared. The material shows a broad potential for application in the fields of tissue engineering, wound dressing and flexible bioelectronic devices. |
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