| 刘艳珍,常一民,范程,等.南极深海来源真菌 Penicillium crustosum PRB-2中1个新的二酮哌嗪类化合物（英文）[J].中国海洋药物,2023,42(1):7-11. |
| 南极深海来源真菌 Penicillium crustosum PRB-2中1个新的二酮哌嗪类化合物（英文） |
| One new diketopiperazine from Antarctic marine-derived fungusPenicillium crustosum PRB-2[1] |
| 投稿时间：2022-02-07 修订日期：2022-03-07 |
| DOI： |
| 中文关键词: 二酮哌嗪 南极；海洋源真菌 青霉菌 抗氧化生物活性 |
| English Keywords:diketopiperazine Antarctic marine-derived fungus Penicillium crustosum antioxidant bioactivity |
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| 中文摘要: |
| 目的 通过OSMAC策略，研究南极海洋来源真菌Penicillium crustosum PRB-2的次级代谢产物。 方法 采用硅胶柱层析、Sephadex LH-20凝胶柱层析、高效液相色谱等分离方法对菌株发酵提取物进行分离纯化； 运用NMR、MS等现代波谱学方法，确定化合物结构；通过活性筛选评价化合物活性。 结果 从P. crustosum PRB-2中分离到1个新化合物chainstatin (1) 和2个已知化合物。 化合物1是首次报道在吲哚苯环5位被侧链2-甲基戊-2-醇取代的二酮哌嗪类化合物。化合物1具有较弱的抗氧化活性，IC50值为298 μΜ。 |
| English Summary: |
| Objective To study the metabolites of Antarctic marine-derived fungus Penicillium crustosum PRB-2 by one strain many compounds (OSMAC) strategy. Methods Silica gel column chromatography, Sephadex LH-20 gel column chromatography, HPLC and other separation methods were used to isolate and purify the fermented extracts of the strain；NMR, MS and other modern spectroscopic methods were used to determine the structure of the compounds; The activity of compounds was evaluated by activity screening. Results One new compound, chainstatin (1) and two known compounds were isolated from the P. crustosum PRB-2. Compound 1 was a novel structure diketopiperazinewhich the 5-position of the indole benzene ring was substituted by the 2-methylpentan-2-ol block, naturally occurring for the first time. Compound 1 exhibited weak antioxidant activity with an IC50 value of 298 μM. |
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